Ankylosing spondylitis is a chronic inflammatory condition that affects the spine and sacroiliac joints. It is a type of arthritis that causes stiffness, inflammation, and pain in the back. While the root cause of ankylosing spondylitis is not yet known, it is believed to be a combination of genetic and environmental factors.
Genetic predisposition plays a significant role in developing ankylosing spondylitis. It is more prevalent among individuals who have a specific gene called HLA-B2 However, not everyone with this gene develops the condition. Therefore, the precise genetic mechanisms underlying the disease remain a mystery.
Environmental factors may also contribute to the development of ankylosing spondylitis. For example, smoking and exposure to certain bacteria may trigger the onset of the condition. These factors may interact with genetic factors in susceptible individuals, leading to the development of ankylosing spondylitis.
While the root cause of ankylosing spondylitis remains unknown, it is clear that it is a combination of genetic and environmental factors. If you experience symptoms of back pain, stiffness and limited spinal mobility, see your doctor. Early diagnosis and prompt management can significantly improve the long-term outcome.